a major health risk of chewing tobacco is Risks Risks of tobacco

Indian J Med Res Supplemen 148(1):4145

Other factors that may increase the chances of developing smokers leg include: smoking being over the age of 60 years having overweight or obesity diabetes high blood pressure high cholesterol a family history of PAD, heart disease, or stroke chronic kidney disease or being on dialysis Many people with smokers leg experience no signs or symptoms

Smoking is known to generally suppress the immune systems capacity to fight infection, and one would expect smokers to be particularly susceptible to a novel respiratory disease

Evil Laugh: Nick O'Teen does the "nyeh heh heh" variety in the first TV ad, when some kids are about to take the cigarettes he's offering

Thanks for the clip Gar